DURING when we want to talk about something that happened:
My grandfather was killed during the war.
from the beginning to the end of a period of time:
During the summer she worked as a baby-sitter.
FOR when we want to talk about how long something lasts:
The season only lasts for some months.
It can be used with all tenses:
They study for two hours every day.
They are studying for two hours today.
I worked at the bank for five years.
I've worked at this company for ten years.
SINCE when we want to show points to the beginning of a period of time:
He has been living in London since 1997.
We've known about it since June.
It is normally used with the Present Perfect:
He has been here since his childhood.
It can also be used in the structure:
It is a year since I saw her.
WHILE when we refer to certain actions:
While I was eating lunch, I read this book.
Please,don't drink alcohol while driving.
It is always followed by a subject and a verb:
...while the man was riding his bicycle.
...while the children were singing.
Both SINCE and FOR also have other meanings, with no reference to time:
This is for you.
Since he didn't study, he didn't pass the exam.